D-instantons are Euclidean (-1)-brane solutions of type IIB supergravity, which have been used to compute non-perturbative corrections to the effective action of type IIB string theory. I will discuss the most general non-extremal, non-supersymmetric generalization to the D-instanton. By repeating the calculations for arbitrary dimensions and dilaton coupling we will see that these solutions can be viewed as wormholes of non-extremal Reissner-Nordstroem black holes in one higher dimension. I will also discuss the role of D-instantons in the context of AdS/CFT and make a conjecture about the CFT counterpart of these non-extremal solutions.