I will discuss the partition function of 4d N=1 theories on Hopf surfaces. These are diffeomorphic to S^1 x S^3 and the partition function provides a path integral realization of the supersymmetric index. Its large S^1 limit exhibits a universal behaviour associated to the existence of a Casimir energy. I will argue that, contrarily to the non-supersymmetric case, this Casimir energy is a physical (non-ambiguous) quantity in supersymmetric theories.