The spectral problem for N=4 Super Yang-Mills can be formulated as a set of quantisation conditions on a handful of functions called Q-functions. Recent analysis suggests that the Q-functions can be used as simple building blocks for 3-point correlation functions. This strongly resembles the situation in integrable spin chains where the wave functions factorise into a simple product of Q-functions in a special basis called Sklyanin’s separation of variables (SoV) basis which is one of the most powerful approaches for solving integrable systems. Unfortunately this framework has only been developed for the simplest integrable spin chains with sl(2) symmetry, far from the psu(2,2|4) needed to describe N=4 SYM. In this talk I will review recent advances in developing the SoV approach for higher rank integrable spin chains. I will explain how to construct the SoV basis in a systematic fashion and how it links to the representation theory of the system. Next, I will discuss a new approach for obtaining the measure in separated variables based on the famous Baxter TQ equation and how the approach naturally provides a large family of correlation functions as very simple determinants in Q-functions. I will briefly discuss how the approach can be applied directly to certain 4d QFTs, in particular the fishnet cousin of N=4 SYM.