Mathematical ideas introduced by Ramanujan a century ago in number theory and combinatorics have come to play a surprising role in understanding some deep and fundamental aspects of quantum gravity and quantum field theory in three very distinct contexts of holography, duality, and topology. In this colloquium, I shall first describe the fascinating history, physics, and mathematics behind this rich and fruitful connection focusing on the role (mock) modular forms have come to play in understanding quantum properties of black holes in string theory. I shall then elucidate briefly the manifestations of mock modularity in physics in its other avatars.